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Milbemycin
also known as Interceptor
This product is packaged in both English and a foreign language.
Milbemycin is an oral broad-spectrum anthelmintic tablet for the prevention of heartworm disease and the control of roundworms, hookworms and whipworms in dogs.
Product Type
Milbemycin is an oral broad-spectrum anthelmintic tablet for the prevention of heartworm disease and the control of roundworms, hookworms and whipworms in dogs.
Properties
Milbemycin oxime belongs to the group of macrocyclic lactones, isolated from the fermentation of Streptomyces hygroscopicus var. aureolacrimosus. It is active against mites, against larval and adult stages of nematodes as well as against larvae of Dirofilaria immitis.
Properties
Milbemycin oxime belongs to the group of macrocyclic lactones, isolated from the fermentation of Streptomyces hygroscopicus var. aureolacrimosus. It is active against mites, against larval and adult stages of nematodes as well as against larvae of Dirofilaria immitis.
The activity of milbemycin is related to its action on invertebrate neurotransmission: Milbemycin oxime, like avermectins and other milbemycins, increases nematode and insect membrane permeability to chloride ions via glutamate-gated chloride ion channels (related to vertebrate GABAA and glycine receptors). This leads to hyperpolarisation of the neuromuscular membrane and flaccid paralysis and death of the parasite.
Milbemycin is well tolerated by dogs of all ages and breeds, including Collies and breeding animals.
Indications
Milbemycin is indicated for the prevention of heartworm (Dirofilaria immitis) disease and the treatment and control of roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum) and whipworms (Trichuris vulpis) in dogs.
In some European countries additional indications for nematodes and mites are available:
Angiostrongylus vasorum, Crenosoma vulpis
Mites: Demodex canis, Sarcoptes, Pneumonyssoides caninum
Dosage and Administration
Milbemycin is given orally at the minimum dose of 0.5 mg milbemycin oxime per kg body weight according to the following table:
| Color |
Weight (lb) |
Weight (kg) |
milbemycin oxime |
| Brown |
2 - 10lbs |
1 - 4kg |
2.3mg |
| Green |
11 - 25lbs |
4 - 11kg |
5.75mg |
| Yellow |
26 - 50lbs |
11 - 22kg |
11.5mg |
| Blue |
51 - 100lbs |
22 - 45kg |
23mg |
Dogs over 45 kg are given an appropriate combination of tablets.
Milbemycin must be given at monthly intervals, preferably on the same date starting within 1 month from the beginningof the heartworm transmission season and continuing until 1 dose after its end. Where heartworm transmission is not seasonal, Milbemycin is given throughout the year. Dogs living in heartworm-free regions and travelling to heartworm risk areas should be treated within 1 month from the beginning of the exposure to transmission. Treatment should be repeated monthly until 1 administration after the end of the exposure risk. If Milbemycin replaces another heartworm prevention the first dose should be given within 1 month after the previous treatment. The tablets can be given directly into the mouth of the dog or in a portion of food.
Special Precautions and Warnings
In heartworm risk areas or if it is known that the dog has been travelling in heartworm risk regions, dogs should be tested for heartworm infection. Heartworm prevention programs should be started only in dogs found to be uninfected.
On rare occasions, reactions such
as vomiting, diarrhoea, depression/lethargy and itching have been seen in
treated dogs. If this product is overdosed, transient unsteadiness, trembling, depression, salivation and enlarged pupils may
occur for up to approximately 24 hours.
This product may be used in pregnant females, breeding
males and females, and puppies from 2 weeks of age.
Storage:
Store below 25 deg. C (air
conditioning), away from direct sunlight.
Manufacturer :
Novartis Animal Health
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